NYU Dataset
Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma
Part of: Lund Lab |
UID: 10601
- Description
CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic vessels direct CD8+ T cell sequestration at the tumor periphery. This dataset includes flow cytometry, TCR sequencing, RNA sequencing, and immunohistochemistry data. The data indicate that the lymphatic vasculature helps tune the diversity and functional state of the intratumoral CD8+ T cell repertoire.
CXCL12fl/fl mice
Prox1-tdTomato mice
BRafV600E mice
BPC mice
Ptenfl/fl mice
YUMM1.7 cells
Tyr::Cre-ER mice
YUMMER1.7 cells
Kaede-Tg mice
MCA205 cells
K14-VEGFR3-Ig mice
MCA205.OVA cells
CXCL12-dsRedE2 mice
B16.F10 cells
C57BL/6J mice
Prox1:Cre-ERT2 mice
B16.F10.OVA cells
CD45.1+ mice
CXCR4fl/fl-UBC-CreERT2 mice
MC38 cells
OT-1 mice
OT1-Kaede-Tg mice
LN stromal cells
Ai14 mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Application RequiredAuthor Approval Required
- Instructions
- Please complete the Data Request Form to request access to this dataset. The information included in the form will be sent to the Corresponding Author who will evaluate your request for their data. The Corresponding Author may ask you to provide additional information if necessary.
Leica Aperio ImageScope AT
- Grant Support
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Lloyd J. Old STAR Program/Cancer Research Institute403181/Melanoma Research AllianceBrenden-Colson Center for Pancreatic Care/Brenden-Colson Center for Pancreatic CareSU2C-AACR-DT14-14/Stand Up to Cancer2016-00215/Swedish Research Council
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