This dataset was collected to show that there is a decline in cytotoxic T cells and TCR clonality in organ transplant recipients (OTRs) with squamous cell carcinoma (SCC). In this study, 5 SCC tumor samples and 6 transplant-associated SCC (TSCC) tumor samples were analyzed. Among SCC samples, the male to female ratio was 3 to 2 and the mean patient age was 81 years. Among TSCC samples, the male to...

Ultraviolet radiation (UVR) from the sun is the major cause of skin cancer. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, still remains unclear. For this study, human HaCaT keratinocytes were exposed to a single dose or 5 repetitive doses of ssUVR. Analyses of gene expression profiles and functional annotation were performed at 24 hours after irradiation....

Generation R is an ongoing prospective cohort study of child development from the prenatal period through young adulthood in a multi-ethnic population recruited from the Rotterdam, Netherlands metropolitan area. The study enrolled 9,778 mothers with a delivery date between April 2002 and January 2006; they had 9,749 live births. The primary objective of the study is to identify early environmental...

This study described human psoriasis (PsO), which is a prototypic immune-mediated condition with a high predilection for extra-cutaneous involvement. Although the cellular and molecular features of human inflammatory skin diseases have been identified, their tissue context and systemic impact remains unclear. Spatial transcriptomics was performed to explain the cellular landscape of both healthy and...

Since 2002, the Interdisciplinary Melanoma Cooperative Group (IMCG) at Perlmutter Cancer Center has maintained one of the largest clinicopathologic resources, the Melanoma Clinicopathological-Biospecimen Database and Repository, for research on patients 18 years old and over with melanoma or at high risk for melanoma. Clinical data is stored in a secure REDCap database which contains 653 fields to...

This study described DNA methylation changes that accompany metastatic progression in melanoma patients and found localized methylation changes in the regulatory region of NR2F2. NR2F2 is an orphan-nuclear receptor that is essential for embryonic and neural crest cell (NCC) development. For this study, they examined DNA methylation profiles of NCCs and melanocytes as well as melanoma patient tissues...

Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...

Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...