Spatial Transcriptomics Stratifies Psoriatic Disease Severity
- Description
This study described human psoriasis (PsO), which is a prototypic immune-mediated condition with a high predilection for extra-cutaneous involvement. Although the cellular and molecular features of human inflammatory skin diseases have been identified, their tissue context and systemic impact remains unclear. Spatial transcriptomics was performed to explain the cellular landscape of both healthy and psoriatic skin. They analyzed 25 healthy, active lesion, and clinically uninvolved skin biopsies for this study. This dataset includes single cell RNA sequencing data. The data suggests that mild and severe forms of PsO have distinct molecular features and severe PsO may profoundly alter the cellular and metabolic composition of distal unaffected skin sites.
Access
- Restrictions
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Free to All
- Instructions
- RNA sequencing data is publicly available at Gene Expression Omnibus (GEO). Code used for data analysis of single cell and spatial RNA sequencing is deposited in Zenodo. RDS files and other processed data is also deposited in Zenodo. All other data needed to support the conclusions in this paper can be found on PubMed Central (PMC) under Supplementary Materials.
- Grant Support
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Pew-Stewart Scholars for Cancer Research/Pew Charitable TrustsTranslational Immunology Center/NYU Langone HealthRobertson Stem Cell Investigator Award/New York Stem Cell FoundationPackard Fellowship for Science and Engineering/David and Lucile Packard FoundationScientist Development Award/Rheumatology Research FoundationPsoriatic Disease Research Fellowship/National Psoriasis FoundationEarly Career Research Grant/National Psoriasis FoundationPilot Research Grant in Rheumatology/Dermatology/Group for Research and Assessment of Psoriasis and Psoriatic Arthritis