The Atherosclerosis Risk in Communities (ARIC) Study is a prospective longitudinal epidemiological study conducted in four U.S. communities in North Carolina, Massachusetts, Maryland, and Minnesota. ARIC is designed to investigate the causes of atherosclerosis and its clinical outcomes, and variations in cardiovascular risk factors, medical care, and disease by race, gender, location, and date. ARIC...

The Framingham Heart Study (FHS) is an ongoing cohort study dedicated to identifying common factors or characteristics that contribute to cardiovascular disease (CVD). It is a collaborative project of the National Heart, Lung and Blood Institute and Boston University. In 1948, an original cohort of 5,209 men and women between 30 and 62 years old were recruited from Framingham, MA. An Offspring Cohort...

The Women's Health Initiative (WHI) is a longitudinal national health study sponsored by the National Heart, Lung, and Blood Institute (NHLBI) that focuses on strategies for preventing heart disease, breast cancer, colorectal cancer, and osteoporotic fractures in postmenopausal women in the United States. The study includes data from 161,808 women aged 50-79 years old at the time of enrollment. Available...

This data contains information on patients with neurofibromatosis type 1 and neurofibromatosis type 2 and schwannomatosis. The neurofibromatoses (NF) are rare disorders with variation in clinical manifestations, and the NF Registry was created to assist researchers in studying the disease. Patients are included in the registry if they meet the diagnostic criteria for one of the three NF conditions....

This data was created and compiled as researchers built genome-scale gold-standard networks of direct regulatory interactions in Saccharomyces cerevisiae that incorporate binding and gene knockout data. The research team used seven performance measurements to see the accuracy of eighteen statistics association-based approaches for de-novo network reverse-engineered in 13 different datasets spanning...

The dataset includes 864 genomic sequences obtained from COVID-19 patients aged 18 years old and above within the NYU Langone Health system between March 12 and May 10, 2020. Patients reflected the health system's catchment area (i.e., the greater New York City metropolitan area). rRNA-depleted total RNA was sequenced, underwent quality control, and analyzed to produce phylogenetic trees. Further...

This dataset includes 330 Emirati adults participating in the UAE Healthy Future Study-Pilot (UAEHFS-pilot) who provided mouthwash samples. There were 225 non-smokers and 105 smokers who used cigarettes, dokha, shisha, or a combination of tobacco products. 101 of the 105 smokers were male. Tobacco use and frequency were assessed with a structured questionnaire and urine cotinine lab results. Gene...

This dataset from the North American SUDEP Registry represents an ongoing collaborative effort to collect clinical information, tissue, and DNA to support research on clinical research factors for Sudden Unexpected Death in Epilepsy (SUDEP) and other causes of epilepsy-related deaths. For enrollment in the registry, at least one of the following criteria was satisfied: SUDEP within the last five...

With an emphasis on reaching historically underrepresented populations, the All of Us Research Program recruits adults aged 18 and above across the United States to share their health data to enable new insights into human health and research on precision medicine. Participants contribute electronic health records (EHR), survey responses, biospecimens, wearable devices (biometrics), and physical measurements....

To construct a fixed time-scaled phylogenetic tree, the investigators combined 828 viral genome sequences obtained from COVID-19 patients at NYU Langone Health between March and May 2020 with 1,899 background sequences that were contributed to the Nextstrain repository. A total of 2,727 SARS-CoV-2 genomic sequences are available in the dataset. The supporting R code included with the dataset will produce...