This dataset is a product of an investigation of microbe-metabolite relationships in the gut as a means to understand and potentially reduce colorectal cancer (CRC) risk. Microbiota and metabolomics profiling was performed on lyophilized feces from 42 colorectal cancer cases and 89 matched controls. Multivariable logistic regression was used to identify statistically independent associations with CRC....

CONTAIN COVID-19 was a randomized, double-blinded, phase 2 controlled trial which examined the safety and efficacy of convalescent plasma versus a placebo (saline solution) to treat patients who were hospitalized with COVID-19. Inclusion criteria: Being at least 18 years of age Hospitalization with laboratory-confirmed COVID-19 At least one respiratory sign or symptom: cough, chest pain, shortness...

Investigators obtained high quality SARS-CoV-2 sequences from 132 vaccinated and 283 unvaccinated individuals who were seen at NYU Langone Health facilities between May 1, 2021 and August 3, 2021. Fully vaccinated individuals received either two doses of the BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) vaccines, or a single-dose of the COVID-19 Janssen vaccine. Breakthrough infections were defined...

Study investigators examined blood samples from participants in the NYU Women’s Health Study (NYUWHS)--a cohort of 14,274 women enrolled between 1985 and 1991 through a breast cancer screening center in New York City--to identify autoantibodies associated with healthy women. The blood samples were collected at the time of enrollment and at annual screening visits until 1991 and long term follow-up...

To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...

This study described human psoriasis (PsO), which is a prototypic immune-mediated condition with a high predilection for extra-cutaneous involvement. Although the cellular and molecular features of human inflammatory skin diseases have been identified, their tissue context and systemic impact remains unclear. Spatial transcriptomics was performed to explain the cellular landscape of both healthy and...

CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...

SHP2 plays critical roles in normal cell signaling and SHP2 inhibitors alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. This study showed that inhibiting the SHP2/RAS/ERK pathway triggers upregulation of CXCR2 ligands. In this study, C57BL/6J mice were used as the orthotopic allograft lung cancer model. They injected KP cells into the...

Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...

Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...