NYU Dataset
Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in Non-Small Cell Lung Cancer
UID: 10630
- Description
SHP2 plays critical roles in normal cell signaling and SHP2 inhibitors alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. This study showed that inhibiting the SHP2/RAS/ERK pathway triggers upregulation of CXCR2 ligands. In this study, C57BL/6J mice were used as the orthotopic allograft lung cancer model. They injected KP cells into the tail vein of each mouse and MRI was used to monitor tumor formation and progression. Mice were treated with vehicle or SHP099 daily by oral gavage. For CXCR1/2 inhibitor studies, mice were dosed with SX-682, either alone or in combination with SHP099. This dataset includes RNA sequencing data.
H1373 cells
H2122 cells
H23 cells
Calu-1 cells
H1975 cells
H1650 cells
HCC827 cells
PC-9 cells
HEK293T cells
H358 cells
C57BL/6J mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- All the raw sequencing reads are deposited in Gene Expression Omnibus (GEO) database.
- Grant Support
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