This dataset includes 3D scanning electron microscopy (SEM) images of a female mouse corpus callosum and MATLAB code for random walker (RaW) segmentations of myelinated axons. The code additionally characterizes inner axonal diameters and fiber orientation dispersion within segments of the intra-axonal spaces and myelin sheaths. In the study, a female 8-week-old C57BL/6 mouse was perfused trans-cardiacally...

The dataset contains data collected from twelve Balb/c mice with metastatic breast cancer (4T1 mammary tumors). Six mice were in the control group and six mice were treated with 5-Fluorouracil (5FU) for metronomic chemotherapy for two weeks. Diffusion MRI (dMRI) and Dynamic Contrast-enhanced MRI (DCE-MRI) images were collected at baseline and post-treatment. Immunohistochemically (IHC) stains and measurements...

Arboviruses are caused by a group of viruses spread to people (host) by the bite of infected insects (vector). It is within these hosts that arboviruses replicate and undergo genomic evolution. However, how arboviruses evolve, are transmitted, or cause disease in nature remain unclear. Therefore, this study established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice to...

The data from this study shows that early-life antibiotic use may affect the progression of subsequent disease conditions by changing host microbiota and immunologic development. For this study, they used a murine model of dextran sodium sulfate (DSS)-induced colitis and evaluated the effect on disease outcomes of early-life pulsed antibiotic treatment (PAT). The dataset includes 16S sequencing data....

This study investigated the pathways important for Mycobacterium tuberculosis, bacteria that cause tuberculosis, pathogenesis. They searched the Mycobacterium tuberculosis genome for open reading frames and identified an operon, Rv3679-Rv3680. This operon is predicted to encode proteins with ATPase activity. Using structure prediction modeling, they found that Rv3679 and Rv3680 have some structural...

The Allen Mouse Brain Atlas is a three-dimensional atlas of gene expression throughout the adult mouse brain. The atlas is separated into four key features:In Situ Hybridization (ISH) Data includes image data with cellular level resolution. To find gene expression data, search can be performed using Gene Search, Differential Search, Fine Structure Search, Bulk Search, and Human Differential Search.Reference...

This study examined changes in membrane potential dynamics of dorsolateral striatal neurons comparing naive mice and expert mice trained to lick a reward spout in response to whisker deflection. In the study, the mice were implanted with a light-weight metal head-post and a recording chamber. The position of the DLS was stereotaxically marked at the surface of the skull and the animals were returned...

Magnetic resonance imaging (MRI) can image brain structure non-invasively and without ionizing radiation. However, inferring histopathological information from MRI remains challenging due to lack of direct links between MRI signals and cellular structures. This study showed that deep convolutional neural networks can estimate histological staining intensity directly from MRI signals developed using...

Basal forebrain cholinergic neuron (BFCN) degeneration is an indicator of Down syndrome (DS) and Alzheimer’s disease (AD). The Ts65Dn (Ts) mouse model recapitulates both cognitive and morphological deficits of DS and AD, including BFCN degeneration. Therefore, this study used Ts mice to understand mechanisms underlying BFCN degeneration to identify novel targets for therapeutic intervention. They performed...

Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...