Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning
- Description
This study examined changes in membrane potential dynamics of dorsolateral striatal neurons comparing naive mice and expert mice trained to lick a reward spout in response to whisker deflection. In the study, the mice were implanted with a light-weight metal head-post and a recording chamber. The position of the DLS was stereotaxically marked at the surface of the skull and the animals were returned to their home cage for five to seven days of recovery after the surgery.
They recorded from three distinct cell types:
- Striatonigral neurons
- Striatopallidal neurons
- Putative cholinergic striatal neurons
The task learning was followed by cell type-specific changes in the membrane potential dynamics induced by the whisker deflection and licking in successfully-performed trials. The dataset contains electrophysiology, imaging, and behavioral data. The publication also contains supplementary data, which includes a table. The table contains data about the numbers of mice and neurons in different experimental groups.
Access
- Restrictions
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Free to All
- Instructions
- The complete dataset and Matlab analysis code is freely available at the Open Access CERN database Zenodo.
- Grant Support
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Career Awards for Medical Scientists/Burroughs Wellcome Fund31003A 182010/Swiss National Science FoundationERC-2011-ADG 293660/European Research CouncilBBRF Young Investigator Grant/Brain & Behavior Research Foundation