NYU Dataset

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Part of: Sippy Lab |
UID: 10500
* Corresponding Author
Description

This study examined changes in membrane potential dynamics of dorsolateral striatal neurons comparing naive mice and expert mice trained to lick a reward spout in response to whisker deflection. In the study, the mice were implanted with a light-weight metal head-post and a recording chamber. The position of the DLS was stereotaxically marked at the surface of the skull and the animals were returned to their home cage for five to seven days of recovery after the surgery.

They recorded from three distinct cell types:

  • Striatonigral neurons
  • Striatopallidal neurons
  • Putative cholinergic striatal neurons

The task learning was followed by cell type-specific changes in the membrane potential dynamics induced by the whisker deflection and licking in successfully-performed trials. The dataset contains electrophysiology, imaging, and behavioral data. The publication also contains supplementary data, which includes a table. The table contains data about the numbers of mice and neurons in different experimental groups.

Subject of Study
Keywords

Access

Restrictions
Free to All
Instructions
The complete dataset and Matlab analysis code is freely available at the Open Access CERN database Zenodo.
Associated Publications
Data Type
Equipment Used
Molecular Devices MultiClamp 700B
Software Used
Fiji
MATLAB
Grant Support
Career Awards for Medical Scientists/Burroughs Wellcome Fund
31003A 182010/Swiss National Science Foundation
ERC-2011-ADG 293660/European Research Council
BBRF Young Investigator Grant/Brain & Behavior Research Foundation