This data was generated in a study to characterize brain bioenergetics in a cohort of clinically and cognitively normal women between the ages of 40 and 50 at different endocrine transition states including premenopause (n = 15), perimenopause (n = 14), and postmenopause (n = 14) in order to study the increased risk for Alzheimer’s disease in women. All subjects received clinical, laboratory, and neuropsychological...

Neuroanatomical Age Prediction Using R (NAPR) is a framework that provides network-based access to predictive modeling software running on a persistent Amazon Web Services (AWS) computing instance. External users may estimate the age of individual subjects using cortical thickness maps derived from their own locally processed T1-weighted whole brain MRI scans. The model was trained using healthy control...

The NYU Alzheimer’s Disease Research Center (NYU ADRC) maintains a large database of standardized clinical and neuropathological research data collected at NYU Langone Health for local investigators, as well as those at affiliated or collaborating institutions. The NYU ADRC database includes a cumulative record of over 1,500 subjects enrolled since 1972. Data was collected every two years until 2005...

This dataset was collected for a study to replicate previous work on hippocampal physiology predictive of successful encoding using an associative memory paradigm in a surgical intracranial electroencephalography (iEEG) group and extend those investigations to a chronic ambulatory iEEG population using RNS System devices (NeuroPace, Inc.). The primary objective was to compare the hippocampal gamma...

This deidentified imaging dataset is comprised of raw k-space data in several sub-dataset groups. Raw and DICOM data have been deidentified via conversion to the vendor-neutral ISMRMRD format and the RSNA Clinical Trial Processor, respectively. Manual inspection of each DICOM image was also performed to check for the presence of any unexpected protected health information (PHI), with spot checking...

This dataset is composed of eight bilateral silicon-probe multi-cellular electrophysiological recordings performed on four male Long-Evans rats. These recordings were performed to assess the effect of novel spatial learning on hippocampal CA1 neural firing and LFP patterns in naïve animals. Each session consisted of a long (~4 hour) PRE rest/sleep epoch home-cage recordings performed in a familiar...

The data set contains recordings made from multiple anterior thalamic nuclei, mainly the antero-dorsal (AD) nucleus, and subicular areas, mainly the post-subiculum (PoS), in freely moving mice. Thalamic and subicular electrodes yielding high number of the so-called Head-Direction (HD) cells were likely to be located in the AD nucleus and the PoS, respectively. Electrode placement was confirmed by histology....

The data set contains multichannel simultaneous recordings made from layer CA1 of the right dorsal hippocampus of three Long-Evans rats during open field tasks in which the animals chased randomly placed drops of water or pieces of Froot Loops while on an elevated square platform. In order to examine the temporal relationships between theta oscillations and the coordination of neuronal firing in the...

This dataset contains recordings made using a silicon probe from three areas from a single rat that was performing different behavioral tasks. The three regions recorded from are left and right hippocampal CA1 and right entorhinal cortex. The tasks are a left/right alternate selection task, wheel running, and platform exploration. The neural data was recorded on 125 channels. In the study, five...

This dataset of multi single neuron recordings was acquired from three rats (EE, FF, GG) while they performed a working memory task. Neuronal activity was monitored simultaneously in the PFC (64 channels) and the intermediate CA1 (32 channels) of the hippocampus. In one rat (EE), sleep was also recorded before and after the task. The data was obtained during 52 main recording sessions and nine short...