NYU Data Catalog

NYU Dataset

Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery

UID: 10178
Author(s): Lisa Mosconi*, Russell H. Swerdlow, Mony de Leon, Richard S. Isaacson, Shankar Vallabhajosula...
* Corresponding Author
Description
This data was generated in a study to characterize brain bioenergetics in a cohort of clinically and cognitively normal women between the ages of 40 and 50 at different endocrine transition states including premenopause (n = 15), perimenopause (n = 14), and postmenopause (n = 14) in order to study the increased risk for Alzheimer’s disease in women. All subjects received clinical, laboratory, and neuropsychological examinations, 18F-fluoro-deoxyglucose (FDG)-Positron Emission Tomography (PET) FDG-PET scans, and platelet mitochondiral cytochrom oxidase (COX) activity measures.
Timeframe
2010 - 2015
Subject of Study
Homo sapiens
Subject Domain
Chronic Disease
Neuroscience
Risk Factors
Population Age
Adult (19 years - 64 years)
Subject Gender
Female
Keywords
Adults
Alzheimer's Disease
Biomarkers
Brain
Brain Diseases
Chronic Disease
Cognitive Disorders
Hormones
Menopause
Neurologic Examination
Neuropsychological Tests
Perimenopause
PET
Postmenopause
Premenopause
Risk Factors
Women's Health

Access

Restrictions
Free to All
Instructions
Study data is freely available for download through the Figshare repository.
Associated Publications
Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, et al. (2018) Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery. PLoS ONE 12(1): e0185926.
Study Type
Observational
Dataset Format(s)
Microsoft Word
Grant Support
R01 AG013616/NIA NIH
R01 AG035137/NIA NIH