This dataset was collected for a study to replicate previous work on hippocampal physiology predictive of successful encoding using an associative memory paradigm in a surgical intracranial electroencephalography (iEEG) group and extend those investigations to a chronic ambulatory iEEG population using RNS System devices (NeuroPace, Inc.). The primary objective was to compare the hippocampal gamma response during associative learning in the RNS System to the gold standard of conventional iEEG recordings. Subjects in this study were asked to complete a face-profession association task. To measure the hippocampal physiology of associative learning, the researcher performed this face-professional paradigm with five patients with convention iEEG and with three patients with chronic iEEG monitored by RNS System, adapting the devices to permit task synchronization to the RNS System iEEG without modifying the clinical system.

Eligible subjects for the study were epilepsy patients between the ages of 18 and 70 years old with previously implanted RNS Systems for treatment of refractory focal epilepsy, had the RNS System with at least one hippocampal depth lead, had a Full-Scale Intelligence Quotient (FSIQ) greater than 70, were able to provide informed consent, and were native English speakers. Patients undergoing surgical evaluation with iEEG monitoring for epilepsy surgery at NYU Langone Health provided comparison data.