This dataset was collected for a study to replicate previous work on hippocampal physiology predictive of successful encoding using an associative memory paradigm in a surgical intracranial electroencephalography (iEEG) group and extend those investigations to a chronic ambulatory iEEG population using RNS System devices (NeuroPace, Inc.). The primary objective was to compare the hippocampal gamma...

This data was collected during clinical examinations at the NYU Comprehensive Epilepsy Center between the years of 2003 and 2008. Subjects included in this dataset have a confirmed epilepsy diagnosis from either routine electroencephalogram (EEG) or video-electroencephalogram (VEEG). The dataset does not include raw EEG data. There are 228 subjects in total. The following information was collected...

This dataset from the North American SUDEP Registry represents an ongoing collaborative effort to collect clinical information, tissue, and DNA to support research on clinical research factors for Sudden Unexpected Death in Epilepsy (SUDEP) and other causes of epilepsy-related deaths. For enrollment in the registry, at least one of the following criteria was satisfied: SUDEP within the last five...

The Human Epilepsy Project (HEP) is a multi-institutional series of prospective, observational studies to identify factors that predict disease outcome, progression, and treatment response among participants with epilepsy. HEP, conducted between 2012 and 2020, included 488 participants aged 12 to 60 years old with new onset focal epilepsy recruited in Australia, Canada, and the United States. Participants...

The Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium is a global project originating from University of Southern California which unites researchers across the fields of imaging genomics, neurology, and psychiatry to understand brain structure and function. ENIGMA consists of 50 active working groups which are organized into four major research cores: Genomics, Disease, Protocol...

Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are associated with dysfunctional mammalian target of rapamycin (mTOR) signaling, which results in increased cell growth and ribosomal S6 protein phosphorylation. TSC studies suggest mTOR inhibitors can reduce TSC tumor growth and seizure frequency, while FCD studies indicate seizure suppression. This study assessed safety of mTOR...

To investigate whether acute SARS‐CoV‐2 infection was associated with (1) amyloidogenic, aggregation‐prone forms of αSyn in the cerebrospinal fluid (CSF), (2) signature of pathogenic changes, and (3) future risk for frank synucleinopathy, the research team compared CSF biomarkers obtained through lumbar puncture for the evaluation of neurologic symptoms from 12 adult patients hospitalized at NYU Langone...

The investigators recruited 14 adult patients undergoing evaluation at NYU Comprehensive Epilepsy Center prior to surgery, 24 healthy volunteers participating in-person, and 60 healthy volunteers participating online for experiments to examine the influence of long-term prior knowledge ('priors') on perception. Bistable perception task: 14 epilepsy patients who were undergoing surgical evaluation...

This study compared the interictal epileptiform discharges (IEDs) of human epilepsy patients from microwire hippocampal recording with those of Alzheimer’s disease (AD) transgenic mice with implanted multilayer hippocampal silicon probes. They investigated the local field potential properties of human IEDs recorded from mesial temporal lobe structures of patients with drug-resistant frontal and temporal...