This study compared the interictal epileptiform discharges (IEDs) of human epilepsy patients from microwire hippocampal recording with those of Alzheimer’s disease (AD) transgenic mice with implanted multilayer hippocampal silicon probes. They investigated the local field potential properties of human IEDs recorded from mesial temporal lobe structures of patients with drug-resistant frontal and temporal lobe epilepsy. In addition, mice were implanted with a two-shank linear silicon probe in the hippocampus spanning the CA1 layers and the upper blade of the dentate gyrus. IEDs were detected in every APP/PS1 mouse at all ages. This dataset contains behavioral and electrophysiology data. The study reveals that IEDs in human epilepsy patients and AD mouse models have similar local field potential characteristics.