NYU Data Catalog

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  • NYU Dataset

    Pre-existing Hippocampal Network Dynamics Constrain Optogenetically Induced Place Fields

    Authors
    Sam McKenzie
    Roman Huszar
    Daniel F. English
    Kanghwan Kim
    3 more author(s)...
    Description

    This study examined how incorporation of synthetic hippocampal signals is constrained by pre-existing circuit dynamics. For this study, they optogenetically stimulated small groups of CA1 neurons as mice traversed a chosen segment of a linear track, which mimicked the emergence of place fields. Mice were trained to run laps on a linear track to retrieve water reward at each end. Before implantation,...

    Subject
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Action-Driven Remapping of Hippocampal Neuronal Populations in Jumping Rats

    Authors
    Laura Green
    David Tingley
    John Rinzel
    Gyorgy Buzsaki
    Description

    Hippocampus plays a key role in navigation guided by environmental inputs. However, a critical aspect of navigation is a sequence of planned and coordinated actions. This study investigated the role of action in the neuronal organization of the hippocampus by training rats to jump a gap on a linear track. For this study, Long-Evans rats were used for recording local field potentials and ensembles of...

    Subject
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Inhibition Allocates Spikes During Hippocampal Ripples

    Authors
    Asako Noguchi
    Roman Huszar
    Shota Morikawa
    Gyorgy Buzsaki
    1 more author(s)...
    Description

    Spike sequences are exemplified by memory replays in sharp-wave ripples (SWRs) and high-frequency oscillations resulting from pyramidal cell-interneuron interactions in the hippocampus. However, the microcircuitry mechanism that enables such flexible spike sequencing remains unknown. This study recorded the membrane potentials of multiple hippocampal CA1 pyramidal cells in mice. For this study, whole-cell...

    Subject
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Task-Selective Place Cells Show Behaviorally Driven Dynamics

    Authors
    Roland Zemla
    Jason J. Moore
    Maya D. Hopkins
    Jayeeta Basu
    Description

    Hippocampal activity supports internal representation of learned experiences and contexts, which allows individuals to form long-term memories. This study investigated hippocampal maps formed under structured attention with learning rules stabilize and maintain task-selectivity during memory recall. They used longitudinal two-photon imaging of hundreds of hippocampal CA1 pyramidal neurons while mice...

    Subject
    Neuroscience
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    Application Required
    Author Approval Required
  • NYU Dataset

    Selection of Experience for Memory by Hippocampal Sharp Wave Ripples

    Authors
    Wannan Yang
    Chen Sun
    Roman Huszar
    Thomas Hainmueller
    1 more author(s)...
    Description

    Experiences need to be labeled during learning for further consolidation, but brain mechanisms that select experiences for lasting memory are unknown. This study determined that successive traversals in the maze were tracked by continuously drifting populations of neurons by combining large-scale neural recordings with a novel application of dimensionality reduction techniques. They recorded from many...

    Subject
    Neuroscience
    Access Rights
    Free to All