Structure Prediction Modeling Characterized Guided Entry of Tail-Anchored Proteins 3 in Mycobacterium Tuberculosis
- Description
This study investigated the pathways important for Mycobacterium tuberculosis, bacteria that cause tuberculosis, pathogenesis. They searched the Mycobacterium tuberculosis genome for open reading frames and identified an operon, Rv3679-Rv3680. This operon is predicted to encode proteins with ATPase activity. Using structure prediction modeling, they found that Rv3679 and Rv3680 have some structural similarity to the guided entry of tail-anchored proteins 3 (Get3). Get3 delivers proteins into the membranes of the endoplasmic reticulum. It is also essential for the normal growth and physiology of some eukaryotes. This study characterized the structures of Rv3679 and Rv3680 and examined if Rv3679 and Rv3680 have a role in Mycobacterium tuberculosis pathogenesis. The dataset contains coordinate and structure factor of ADP, ATPγS, and AMP-PNP.
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- Instructions
- The coordinate and structure factor files of ADP, ATPγS, and AMP-PNP were deposited in Protein Data Bank (PDB).
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