NYU Data Catalog

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Results Found: 5
  • NYU Dataset

    Structural Characterization of Monoclonal Antibodies Targeting Ser404 Region of Phosphorylated Tau Protein

    Authors
    Jessica E. Chukwu
    Erin E. Congdon
    Einar M. Sigurdsson
    Xiang-Peng Kong
    Description

    Tau is one of the major microtubule-associated proteins in neurons. Its main role is to stabilize microtubules, supporting cytoskeletal organization, and axonal transport. Tau may undergo pathological modifications and become hyperphosphorylated. This causes the protein to accumulate into toxic assemblies that collectively lead to neurodegeneration. In Alzheimer's disease, tau proteins change shape...

    Subject
    Neuroscience
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Immune Responses Observed Before and After BNT162b2 mRNA Vaccine Administration in Individuals with and without History of SARS-CoV-2 Infection

    Authors
    Marie I. Samanovic
    Amber R. Cornelius
    Sophie L. Gray-Gaillard
    Joseph Richard Allen
    7 more author(s)...
    Description

    To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2021
    Access Rights
    Free to All
  • NYU Dataset

    Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

    Authors
    Maria M. Steele
    Ian D. Dryg
    Dhaarini Murugan
    Julia Femel
    6 more author(s)...
    Description

    CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...

    Subject
    Cancer
    Genomics
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    Application Required
    Author Approval Required
  • NYU Dataset

    CXCR6 Promotes Dermal CD8+ T Cell Survival and Transition to Long-Term Tissue Residence

    Authors
    Taylor A. Heim
    Ziyan Lin
    Maria M. Steele
    Tenny Mudianto
    1 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...

    Subject
    Genomics
    Access Rights
    Application Required
    Author Approval Required
  • NYU Dataset

    Lymphatic Vessel Transit Seeds Precursors to Cytotoxic Resident Memory T Cells in Skin Draining Lymph Nodes

    Authors
    Taylor A. Heim
    Austin C. Schultz
    Ines Delclaux
    Vanessa Cristaldi
    2 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...

    Subject
    Genomics
    Access Rights
    Application Required
    Author Approval Required