NYU Dataset
KEAP1 Mutation in Lung Adenocarcinoma Promotes Immune Evasion and Immunotherapy Resistance
UID: 10667
- Description
Lung cancer is the leading cause of cancer related deaths worldwide and immunotherapy has become an important therapeutic intervention. Immunotherapy for lung cancer patients often fails with specific mutations like KEAP1. This study examined the impact of KEAP1 mutations on cancer growth and immune surveillance. They generated an orthotopic transplant model of KrasG12D/+; p53-/- lung cancer with cells expressing either a wild-type or a dominant-negative form of Keap1, which is the most frequently listed mutation of KEAP1. The dataset contains single cell RNA sequencing data. These findings provide new insight into the role of KEAP1 mutations in immune evasion.
Keap1fl/fl mice
C57BL/6J mice
OT-1 mice
B6.129S(C)-Batf3tm1Kmm/J mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- Single-cell RNA sequencing data have been deposited at Gene Expression Omnibus (GEO).
- Grant Support
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LF-OC-20-000351/LEO FoundationJudith & Stewart Colton Center for Autoimmunity/NYU Langone HealthWilliam N. Rom Fellowship/William N. Rom FellowshipStony Wold-Herbert Fund/Stony Wold-Herbert FundDanish Cancer Society/Danish Cancer SocietyRSG-17-200-01-TBE/American Cancer SocietyEF Young Investigator Award/Emerald Foundation
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