This study described robust oxytocinergic modulation of intrinsic properties and circuit operations in hippocampal area CA2. For this study, male mice were used for all experiments to avoid variation in oxytocin receptor (OXTR) expression throughout the estrous cycle of female mice. C57BL/6 mice were used in wild-type experiments, while homozygous Oxt-IRES-Cre and hemizygote Amigo2-Cre mice were used...

The medial septum is critical in theta generation by two possible mechanisms: a unitary ‘pacemaker’ timing signal is imposed on the hippocampal system or it may assist in organizing target subcircuits within the phase space of theta oscillations. Therefore, this study used temperature manipulation of the medial septum to test these models. Long Evans rats were implanted with silicon probes and tungsten...

Cortical inhibitory and excitatory inputs are initially mismatched, but become balanced with experience during development. However, how excitatory-inhibitory balance is defined at most synapses, or the mechanisms for maintaining this balance at specific set-points is still unclear. This study demonstrated how coordinated long-term plasticity calibrates populations of excitatory/inhibitory inputs onto...

Lateral entorhinal cortex (LEC) performs important functions for episodic memory processing and coding for contextually salient elements of an environment or experience. This study combined functional circuit mapping and computational modeling to examine the cellular and circuit mechanisms by which long-range glutamatergic LEC projections influence the local activity in the hippocampus. This dataset...

This study compared the interictal epileptiform discharges (IEDs) of human epilepsy patients from microwire hippocampal recording with those of Alzheimer’s disease (AD) transgenic mice with implanted multilayer hippocampal silicon probes. They investigated the local field potential properties of human IEDs recorded from mesial temporal lobe structures of patients with drug-resistant frontal and temporal...

GABAergic interneurons (INs) typically project their axons locally to regulate the excitability of nearby pyramidal cells and other INs. Recent studies on INs focused on subtypes distinguished by expression of Parvalbumin, Somatostatin, or Vasoactive Intestinal Peptide. However, a fourth group that includes neurogliaform cells (NGFCs) has been less well characterized due to a lack of genetic tools....

This study investigated the subthreshold dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies in freely moving mice to understand how excitatory and inhibitory inputs are integrated by neurons. For the study, they recorded and examined large numbers of CA1 pyramidal neurons simultaneously in freely moving CamKIIα-Cre::Ai32 mice. This dataset contains electrophysiology and...

This study developed a ThermoMaze to understand neuronal mechanisms supporting exploratory and consummatory states. ThermoMaze is a behavioral paradigm that allows for the collection of large amounts of physiological data while the animal rests at distinct experimenter-controlled locations. For the study, mice were implanted with a thermistor in the hippocampus. After 5 days of postsurgical recovery,...

Previous studies indicated that the fraction of splitter fields is affected by the delay between responses in a spatial alternation task. This study demonstrated that memory and place field features of both pyramidal cells and interneurons in the hippocampus are interchangeable. They trained two groups of mice with and without delays in one or two environments and examined firing characteristics of...

The hippocampus plays a crucial role in the rapid encoding and storage of episodic memories. This study demonstrated that hippocampal network dynamics are affected by sequential neurogenesis. For the study, they birthdated CA1 pyramidal neurons with in utero electroporation over 4 embryonic days, encompassing the peak of hippocampal neurogenesis, and compared their functional features in freely moving...