Chemogenetic technology designer receptors exclusively activated by designer drugs (DREADD) is a widely used experimental method to control neuronal activity with an exogenous receptor. This study virally expressed an excitatory DREADD in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. For this study, Sprague Dawley rats were used for viral injection and intracranial...

This study described robust oxytocinergic modulation of intrinsic properties and circuit operations in hippocampal area CA2. For this study, male mice were used for all experiments to avoid variation in oxytocin receptor (OXTR) expression throughout the estrous cycle of female mice. C57BL/6 mice were used in wild-type experiments, while homozygous Oxt-IRES-Cre and hemizygote Amigo2-Cre mice were used...

Cortical inhibitory and excitatory inputs are initially mismatched, but become balanced with experience during development. However, how excitatory-inhibitory balance is defined at most synapses, or the mechanisms for maintaining this balance at specific set-points is still unclear. This study demonstrated how coordinated long-term plasticity calibrates populations of excitatory/inhibitory inputs onto...

Medial septum (MS) is important for theta generation by either a unitary pacemaker timing signal imposed on the hippocampal system or assisting in organizing target subcircuits within the phase space of theta oscillations. Therefore, this study used temperature manipulation of the MS to test these models. Long Evens rats were water restricted for 22 hours and trained to perform the behavioral task...

Spike sequences are exemplified by memory replays in sharp-wave ripples (SWRs) and high-frequency oscillations resulting from pyramidal cell-interneuron interactions in the hippocampus. However, the microcircuitry mechanism that enables such flexible spike sequencing remains unknown. This study recorded the membrane potentials of multiple hippocampal CA1 pyramidal cells in mice. For this study, whole-cell...

Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. For this study,...

Lateral entorhinal cortex (LEC) performs important functions for episodic memory processing and coding for contextually salient elements of an environment or experience. This study combined functional circuit mapping and computational modeling to examine the cellular and circuit mechanisms by which long-range glutamatergic LEC projections influence the local activity in the hippocampus. This dataset...

This study compared the interictal epileptiform discharges (IEDs) of human epilepsy patients from microwire hippocampal recording with those of Alzheimer’s disease (AD) transgenic mice with implanted multilayer hippocampal silicon probes. They investigated the local field potential properties of human IEDs recorded from mesial temporal lobe structures of patients with drug-resistant frontal and temporal...

This study investigated the subthreshold dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies in freely moving mice to understand how excitatory and inhibitory inputs are integrated by neurons. For the study, they recorded and examined large numbers of CA1 pyramidal neurons simultaneously in freely moving CamKIIα-Cre::Ai32 mice. This dataset contains electrophysiology and...

GABAergic interneurons (INs) typically project their axons locally to regulate the excitability of nearby pyramidal cells and other INs. Recent studies on INs focused on subtypes distinguished by expression of Parvalbumin, Somatostatin, or Vasoactive Intestinal Peptide. However, a fourth group that includes neurogliaform cells (NGFCs) has been less well characterized due to a lack of genetic tools....