Oxytocin Alters Intrinsic Properties of CA2 Pyramidal Cells to Induce Burst Firing
- Description
This study described robust oxytocinergic modulation of intrinsic properties and circuit operations in hippocampal area CA2. For this study, male mice were used for all experiments to avoid variation in oxytocin receptor (OXTR) expression throughout the estrous cycle of female mice. C57BL/6 mice were used in wild-type experiments, while homozygous Oxt-IRES-Cre and hemizygote Amigo2-Cre mice were used for optogenetic studies. Ai14 mice were crossed with OXTR-IRES-Cre mice, and their offspring were used in imaging experiments. In some experiments, offspring of a cross between PV-Cre mice and Ai9 mice were used. The dataset contains electrophysiology and immunohistochemistry data. This study found that activation of oxytocin receptors drives pyramidal cells in hippocampal area CA2 to fire bursts.
Access
- Restrictions
-
Application RequiredAuthor Approval Required
- Instructions
- Please complete the Data Request Form to request access to this dataset. The information included in the form will be sent to the Corresponding Author who will evaluate your request for their data. The Corresponding Author may ask you to provide additional information if necessary.
- Grant Support
-
McKnight Scholar Award/McKnight FoundationPew Biomedical Scholars/Pew Charitable TrustsMathers Foundation/Mathers FoundationFord Foundation Predoctoral Fellowship/Ford FoundationDruckenmiller Foundation/Druckenmiller FoundationSimons Foundation/Simons FoundationBurnett Family Foundation/Burnett Family FoundationSloan Research Fellowship/Alfred P. Sloan FoundationSkirball Collaborative Research Award/NYU Langone Health