NYU Dataset

Oxytocin Alters Intrinsic Properties of CA2 Pyramidal Cells to Induce Burst Firing

Part of: Tsien Lab |
UID: 10555
* Corresponding Author
Description

This study described robust oxytocinergic modulation of intrinsic properties and circuit operations in hippocampal area CA2. For this study, male mice were used for all experiments to avoid variation in oxytocin receptor (OXTR) expression throughout the estrous cycle of female mice. C57BL/6 mice were used in wild-type experiments, while homozygous Oxt-IRES-Cre and hemizygote Amigo2-Cre mice were used for optogenetic studies. Ai14 mice were crossed with OXTR-IRES-Cre mice, and their offspring were used in imaging experiments. In some experiments, offspring of a cross between PV-Cre mice and Ai9 mice were used. The dataset contains electrophysiology and immunohistochemistry data. This study found that activation of oxytocin receptors drives pyramidal cells in hippocampal area CA2 to fire bursts.

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Associated Publications
Data Type
Equipment Used
Axon Digidata 1322A
Drummond Scientific Nanoject II
Leica VT1000 S
Molecular Devices MultiClamp 700B
Sutter P-2000
Sutter P-97
Zeiss Axioskop 2 FS Plus
Zeiss LSM 510 META
Software Used
GraphPad Prism v6.0
ImageJ
MATLAB
pCLAMP
Grant Support
McKnight Scholar Award/McKnight Foundation
Pew Biomedical Scholars/Pew Charitable Trusts
Mathers Foundation/Mathers Foundation
Ford Foundation Predoctoral Fellowship/Ford Foundation
Druckenmiller Foundation/Druckenmiller Foundation
Simons Foundation/Simons Foundation
Burnett Family Foundation/Burnett Family Foundation
Sloan Research Fellowship/Alfred P. Sloan Foundation
Skirball Collaborative Research Award/NYU Langone Health