GABAergic interneurons (INs) typically project their axons locally to regulate the excitability of nearby pyramidal cells and other INs. Recent studies on INs focused on subtypes distinguished by expression of Parvalbumin, Somatostatin, or Vasoactive Intestinal Peptide. However, a fourth group that includes neurogliaform cells (NGFCs) has been less well characterized due to a lack of genetic tools. Therefore, this study examined if these INs can be accessed experimentally using intersectional genetics with the gene Id2.

The dataset includes supplementary data tied to the publication, which contains source data for figures. It includes Id2 versus non-Id2 cell counts in somatosensory cortex barrel field (S1BF), mRNA counts in Id2 cells, Id2 versus non-Id2 cell counts in prelimbic area, Id2 neuropeptide Y cholecystokinin cell counts in S1BF, and depolarization-induced suppression of inhibition data. In addition, there are source data for electrophysiological parameters.