Inhibitory Conductance Controls Place Field Dynamics in the Hippocampus
- Description
Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. Homozygous CaMKIIa-Cre line T29–1 transgenic mice were crossed with homozygous Ai32 mice to express channelrhodopsin2 in neurons expressing CaMKIIa in F1 hybrid mice. They used 7 male F1 hybrid mice (3 mice for extracellular recordings and 4 for intracellular recordings in head-fixed conditions). This dataset contains extracellular and intracellular recording in head-fixed mice.
Access
- Restrictions
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Free to All
- Instructions
- The data for this study is publicly available in the Buzsaki Lab Databank. All custom code for preprocessing and analyzing the data, and the code for the biophysically realistic model can be found on GitHub.
- Grant Support
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LT0000717/2018/Human Frontiers Science ProgramEMBO ALTF 1161-2017/European Molecular Biology OrganizationRTI2018–098581-B-I00/Spanish Ministry of Science and InnovationFPU17/03268/Spanish Ministry of EducationEST19/00828/Spanish Ministry of Education