NYU Dataset
Inhibitory Conductance Controls Place Field Dynamics in the Hippocampus
Part of: Buzsaki Lab |
UID: 10598
- Description
Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. For this study, T29-1 mice were crossed with Ai32 mice to express channelrhodopsin2 in neurons expressing CaMKIIα. This dataset contains extracellular and intracellular recording in head-fixed mice. The data indicate that the spatial tuning of local inhibition is a fundamental mechanism of both rate and phase coding in the hippocampal CA1 region.
T29-1 mice
Ai32 mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- The data for this study is publicly available in the Buzsaki Lab Databank. All custom code for preprocessing and analyzing the data, and the code for the biophysically realistic model can be found on GitHub.
- Grant Support
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LT0000717/2018/Human Frontiers Science ProgramEMBO ALTF 1161-2017/European Molecular Biology OrganizationRTI2018–098581-B-I00/Spanish Ministry of Science and InnovationFPU17/03268/Spanish Ministry of EducationEST19/00828/Spanish Ministry of Education
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