Chronic Stress Primes Innate Immune Responses in Mice and Humans
- Description
Psychological stress is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes and showed that psychological stress induces remodeling of the chromatin landscape and transcriptomic reprogramming of monocytes. The dataset contains RNA and ATAC sequencing of isolated bone marrow monoctyes from 6 mice (3 stress, 3 control). RNA sequencing of isolated bone marrow monocytes stimulated with lipopolysaccharide of 16 pools of 4 mice each (4 pools control unstimulated, 4 pools stressed unstimulated, 4 pools control stimulated, 4 pools stressed stimulated). In addition, RNA sequencing of isolated whole blood monocytes from humans with high and low stress (12 high stress, 15 low stress).
Access
- Restrictions
-
Free to All
- Instructions
- RNA and ATAC sequencing data have been deposited at Gene Expression Omnibus (GEO).
- Grant Support
-
19CDA34630066/American Heart Association16SFRN28730002/American Heart Association118CDA34110203/American Heart Association18-A0-00-1001884/American Society of Hematology