Chronic Stress Primes Innate Immune Responses in Mice and Humans
- Description
Psychological stress (PS) is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes. They showed that PS induces remodeling of the chromatin landscape and transcriptomic reprogramming of monocytes. For this study, C57BL/6 mice were used for all experiments. This dataset contains RNA and ATAC sequencing data. The data indicate that monocytes from stressed mice and humans exhibit activation of metabolic pathways and reduced chromatin accessibility at mitochondrial respiration-associated loci.
Access
- Restrictions
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Free to All
- Instructions
- RNA and ATAC sequencing data have been deposited at the Gene Expression Omnibus (GEO).
- Grant Support
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19CDA34630066/American Heart Association16SFRN28730002/American Heart Association118CDA34110203/American Heart Association18-A0-00-1001884/American Society of Hematology