NYU Data Catalog

Alternate Title(s): ARIC
Authors: Christie Ballantyne

Lloyd Chambless

Josef Coresh

Matthew Davis

4 more author(s)...
Description: The Atherosclerosis Risk in Communities (ARIC) Study is a prospective longitudinal epidemiological study conducted in four U.S. communities in North Carolina, Massachusetts, Maryland, and Minnesota. ARIC is designed to investigate the causes of atherosclerosis and its clinical outcomes, and variations in cardiovascular risk factors, medical care, and disease by race, gender, location, and date. ARIC...
Subject: Chronic Disease

Health Care System

Population Characteristics

Risk Factors
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Local Expert: Saul Blecker

NYU Dataset

Authors: Tessa J. Barrett

Emma M. Corr

Coen van Solingen

Florencia Schlamp

18 more author(s)...
Description: Psychological stress (PS) is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes. They showed that PS induces remodeling of the chromatin landscape...
Subject: Genomics
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NYU Dataset

Authors: Milessa Silva Afonso

Monika Sharma

Martin Schlegel

Coen van Solingen

11 more author(s)...
Description: MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...
Subject: Genomics
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NYU Dataset

Authors: Laura Senatus

Lander Egana-Gorrono

Raquel Lopez-Diez

Sonia Bergaya

17 more author(s)...
Description: Previous study indicated that the receptor for advanced glycation end products (RAGE) in the progression and regression of atherosclerosis. Therefore, this study examined if Diaphanous 1 (DIAPH1) binds to the RAGE cytoplasmic domain and contributes to progression of atherosclerosis. They intercrossed atherosclerosis prone Ldlr−/− mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks....
Subject: Genomics
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NYU Dataset

Alternate Title(s): MASALA
Authors: Alka Kanaya

Namratha Kandula

Nadia S. Islam
Description: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study examines risk factors for heart disease among South Asians of Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan descent in the United States to guide preventative measures and future treatments. Beginning in 2010, eligible South Asian participants between the ages of 40 and 80 were recruited from the San Francisco...
Subject: Chronic Disease

Genomics

Mental Health

Population Characteristics

Risk Factors
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NYU Dataset

Authors: Natalia Eberhardt

Maria G. Noval

Ravneet Kaur

Letizia Amadori

19 more author(s)...
Description: This study combined multiple techniques (e.g., RNAscope in-situ hybridization, immunohistochemistry, immunofluorescence, single-cell RNA sequencing, bulk RNA sequencing, and functional assays) to investigate the inflammatory response associated with SARS-CoV-2 infection in human vascular tissues. Single cell RNA-sequencing data obtained from samples collected for this study is available via the Gene...
Subject: COVID-19

Infectious Disease

Risk Factors
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