NYU Dataset
DIAPH1 Mediates Progression of Atherosclerosis and Regulates Hepatic Lipid Metabolism in Mice
UID: 10626
- Description
Previous study indicated that the receptor for advanced glycation end products (RAGE) in the progression and regression of atherosclerosis. Therefore, this study examined if Diaphanous 1 (DIAPH1) binds to the RAGE cytoplasmic domain and contributes to progression of atherosclerosis. They intercrossed atherosclerosis prone Ldlr−/− mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks. The dataset includes flow cytometry, immunohistochemistry, and RNA sequencing data. The publication also contains supplementary data. The supplementary data includes source data, uncropped blots, and differentially expressed genes in Ldlr−/− Diaph1−/− mice versus Ldlr−/− mice.
C57BL/6J mice
Ldlr–/– mice
Hepa 1-6 cells
Apobec1−/− mice
Ldlr−/− Diaph1−/− mice
Associated Publications
Data Type
Equipment Used
Software Used
Dataset Format(s)
PDF, Microsoft Excel
Access
- Restrictions
-
Free to All
- Instructions
- Supporting data for the associated publication is available in PubMed Central (PMC) under Supplementary Materials. RNAseq data can be accessed from NCBI's Gene Expression Omnibus (GEO) data repository.
Shimadzu FPLC System
- Grant Support
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Diabetes Research Program/NYU Langone Health
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