NYU Data Catalog

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  • NYU Dataset

    Evaluating Everolimus Molecular Mechanisms in Tuberous Sclerosis Complex and Focal Cortical Dysplasia

    Authors
    Dominique F. Leitner
    Evgeny Kanshin
    Manor Askenazi
    Yik Siu
    6 more author(s)...
    Description

    Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are associated with dysfunctional mammalian target of rapamycin (mTOR) signaling, which results in increased cell growth and ribosomal S6 protein phosphorylation. TSC studies suggest mTOR inhibitors can reduce TSC tumor growth and seizure frequency, while FCD studies indicate seizure suppression. This study assessed safety of mTOR...

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  • NYU Dataset

    Chronic Stress Primes Innate Immune Responses in Mice and Humans

    Authors
    Tessa J. Barrett
    Emma M. Corr
    Coen van Solingen
    Florencia Schlamp
    18 more author(s)...
    Description

    Psychological stress (PS) is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes. They showed that PS induces remodeling of the chromatin landscape...

    Subject
    Genomics
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  • NYU Dataset

    Translational Regulation of TFH Cell Differentiation and Autoimmune Pathogenesis

    Authors
    Preeyam S. Patel
    Sandra Perez-Baos
    Beth Walters
    Margo Orlen
    4 more author(s)...
    Description

    T follicular helper (TFH) cells are CD4+ T helper cells that are important for immune responses to infection and vaccination. This study examined the translational regulation required for CD4+ T helper cells to differentiate to TFH cells and its contribution to TFH cell participation in pathogenesis in autoimmune disease in animal models. The experiments for non-autoimmune studies were performed with...

    Subject
    Genomics
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  • NYU Dataset

    SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

    Authors
    Natalia Eberhardt
    Maria G. Noval
    Ravneet Kaur
    Letizia Amadori
    19 more author(s)...
    Description

    This study combined multiple techniques (e.g., RNAscope in-situ hybridization, immunohistochemistry, immunofluorescence, single-cell RNA sequencing, bulk RNA sequencing, and functional assays) to investigate the inflammatory response associated with SARS-CoV-2 infection in human vascular tissues. Single cell RNA-sequencing data obtained from samples collected for this study is available via the Gene...

    Subject
    COVID-19
    Infectious Disease
    Risk Factors
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