NYU Data Catalog

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  • NYU Dataset

    Chronic Stress Primes Innate Immune Responses in Mice and Humans

    Authors
    Tessa J. Barrett
    Emma M. Corr
    Coen van Solingen
    Florencia Schlamp
    18 more author(s)...
    Description

    Psychological stress (PS) is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes. They showed that PS induces remodeling of the chromatin landscape...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Adipose Tissue Macrophages Adapt to Inflammatory and Metabolic Challenges

    Authors
    Hernandez Moura Silva
    Andre Bafica
    Gabriela Flavia Rodrigues-Luiz
    Jingyi Chi
    13 more author(s)...
    Description

    Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. This study examined ATM subpopulations in steady state and in response to nutritional and infectious challenges. They characterized the epididymal white adipose tissue (eWAT) lymphoid and myeloid cell populations under steady state using RNA sequencing to analyze the transcriptome of...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

    Authors
    Natalia Eberhardt
    Maria G. Noval
    Ravneet Kaur
    Letizia Amadori
    19 more author(s)...
    Description

    This study combined multiple techniques (e.g., RNAscope in-situ hybridization, immunohistochemistry, immunofluorescence, single-cell RNA sequencing, bulk RNA sequencing, and functional assays) to investigate the inflammatory response associated with SARS-CoV-2 infection in human vascular tissues. Single cell RNA-sequencing data obtained from samples collected for this study is available via the Gene...

    Subject
    COVID-19
    Infectious Disease
    Risk Factors
    Access Rights
    Free to All
  • NYU Dataset

    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Authors
    Ellie Ivanova
    Jasmine Shwetar
    Joseph C. Devlin
    Terkild B. Buus
    17 more author(s)...
    Description

    To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All