NYU Data Catalog

NYU Dataset

Authors: Daniel P. Depledge

Kalanghad Puthankalam Srinivas

Tomohiko Sadaoka

Devin Bready

4 more author(s)...
Description: This dataset was collected to show that direct RNA sequencing using nanopore arrays is an alternative to conventional RNA sequencing approaches, which are complicated by high gene density, overlapping reading frames, and complex splicing patterns. In direct RNA sequencing, individual polyadenylated RNAs are sequenced directly. For this study, direct RNA sequencing was used to profile the herpes simplex...
Subject: Genomics
Access Rights: Free to All

NYU Dataset

Authors: Hernandez Moura Silva

Andre Bafica

Gabriela Flavia Rodrigues-Luiz

Jingyi Chi

13 more author(s)...
Description: Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. This study examined ATM subpopulations in steady state and in response to nutritional and infectious challenges. They characterized the epididymal white adipose tissue (eWAT) lymphoid and myeloid cell populations under steady state using RNA sequencing to analyze the transcriptome of...
Subject: Genomics
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NYU Dataset

Authors: Zhi Fang

Xiaoran Sun

Xiang Wang

Ji Ma

6 more author(s)...
Description: Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells (ECs) results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study revealed that genetic depletion of NGBR in ECs results in CCM1/2...
Subject: Genomics
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NYU Dataset

Authors: Alice Fok

Benjamin Brissette

Tim Hallacy

Hassan Ahamed

3 more author(s)...
Description: Caenorhabditis elegans (C. elegans) uses specialized mechanosensory neurons to detect food. These neurons release dopamine to suppress foraging and promote dwelling. This study identified genes highly expressed in dopaminergic food-sensing neurons and screened for defects in the food-triggered slowing behavior mediated by these neurons. They found a K2P-family potassium channel gene TWK-2 that mutates...
Subject: Genomics

Neuroscience
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NYU Dataset

Authors: Preeyam S. Patel

Sandra Perez-Baos

Beth Walters

Margo Orlen

4 more author(s)...
Description: T follicular helper (TFH) cells are CD4+ T helper cells that are important for immune responses to infection and vaccination. This study examined the translational regulation required for CD4+ T helper cells to differentiate to TFH cells and its contribution to TFH cell participation in pathogenesis in autoimmune disease in animal models. The experiments for non-autoimmune studies were performed with...
Subject: Genomics
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NYU Dataset

Authors: Hui-Lan Hu

Kalanghad P. Srinivas

Shuoshuo Wang

Moses V. Chao

5 more author(s)...
Description: Single‐cell RNA sequencing (scRNA‐seq) has not been effectively used for exploring the interactions between the host cell and viral pathogens in latently infected cells. Therefore, this study used scRNA‐seq and single‐molecule sensitivity fluorescent in situ hybridization technologies to investigate host single‐cell transcriptome changes upon the reactivation of a human neurotropic virus, herpes simplex...
Subject: Genomics
Access Rights: Free to All