NYU Dataset
NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage
UID: 10611
- Description
Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study used RNA sequencing analysis to determine the alteration of transcriptomic profiling in human brain microvascular endothelial cells (HBMVECs). For the study, NGBR was knocked down with NGBR small interfering RNA in HBMVECs in vitro. The dataset contains sequencing data. These findings indicate that NGBR-mediated histone acetylation is a potential target for preventing the onset and progression of sporadic CCM.
Access
- Restrictions
-
Free to All
- Instructions
- The sequencing data are deposited in the NCBI’s Gene Expression Omnibus (GEO) database.
Agilent Fragment Analyzer System
PerkinElmer Microplate Reader
- Grant Support
-
GRNT33671180/American Heart Association
Do you have or know of a dataset that should be added to the catalog? Let us know!