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  • NYU Dataset

    Acetyl-L-Carnitine Deficiency in Patients with Major Depressive Disorder

    Authors
    Carla Nasca
    Benedetta Bigio
    Francis S. Lee
    Sarah P. Young
    9 more author(s)...
    Description

    This study identified biological targets in major depressive disorder (MDD). Acetyl-l-carnitine (LAC), which is critical for hippocampal function and several behavioral domains, has rapid and enduring antidepressant like effects in LAC deficient rodents. As a result, this study examined LAC levels in humans. Following an initial phone screen, potential participants were evaluated in person to determine...

    Subject
    Neuroscience
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    Application Required
    Author Approval Required
  • NYU Dataset

    NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage

    Authors
    Zhi Fang
    Xiaoran Sun
    Xiang Wang
    Ji Ma
    6 more author(s)...
    Description

    Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells (ECs) results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study revealed that genetic depletion of NGBR in ECs results in CCM1/2...

    Subject
    Genomics
    Access Rights
    Free to All