NYU Dataset
Single-Cell Transcriptomics Identifies Gadd45b as a Regulator of Herpesvirus-Reactivating Neurons
Part of: Oxytocin U19 BRAIN Initiative |
UID: 10674
- Description
Single‐cell RNA sequencing (scRNA‐seq) has not been effectively used for exploring the interactions between the host cell and viral pathogens in latently infected cells. Therefore, this study used scRNA‐seq and single‐molecule sensitivity fluorescent in situ hybridization technologies to investigate host single‐cell transcriptome changes upon the reactivation of a human neurotropic virus, herpes simplex virus‐1 (HSV‐1). The dataset includes scRNA-seq of HSV-1 latency data. These data indicate HSV‐1 reactivation state in primary neurons is determined by a unique subcellular localization signature of the stress sensor Gadd45b.
293LTV cells
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- All sequencing data generated as part of this study are available on European Nucleotide Archive (ENA).
- Grant Support
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687306/Melanoma Research AllianceSimons Fellows Program/Simons Foundation
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