Cardiac Muscle–Restricted Partial Loss of Nos1ap Expression Has Limited Impact on Electrocardiographic Features
- Description
Previous studies in murine cardiomyocytes and ex vivo knockdown in zebrafish embryonic hearts have demonstrated that NOS1AP expression levels can alter cellular electrophysiology. Therefore, this study generated constitutive and heart muscle-restricted Nos1ap knockout mice to explore the role of NOS1AP in cardiac electrophysiology and QT interval regulation in vivo. To assess the impact of Nos1ap loss on heart transcriptome during development, RNA sequencing was performed in heart tissue from wildtype (males; n=5) and Nos1ap null homozygous (males; n=5) embryonic day 13.5 (e13.5) mice, and assessed for differential gene expression. The data indicate that constitutive loss of Nos1ap has no major widespread impact on transcriptome in e13.5 hearts.
Access
- Restrictions
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Free to All
- Instructions
- RNA sequencing data are accessible on Gene Expression Omnibus (GEO). All other data are provided in the paper on PubMed Central (PMC) under Supplementary Materials.
- Grant Support
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McGovern Medical School at UTHealth/McGovern Medical School at UTHealth