NYU Data Catalog

NYU Dataset

Authors: Milessa Silva Afonso

Monika Sharma

Martin Schlegel

Coen van Solingen

11 more author(s)...
Description: MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...
Subject: Genomics
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NYU Dataset

Authors: Chantal J. M. van Opbergen

Joseph Sall

Chris Petzold

Kristen Dancel-Manning

2 more author(s)...
Description: Previous studies showed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. This study combined pre-embedding immunolabeling with serial block-face scanning electron microscopy (SBF-SEM) to visualize and examine the gap junction plaque morphology. They used a murine model of cardiomyocyte-specific Tamoxifen (TAM) activated...
Subject: Cell Physiology
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NYU Dataset

Authors: Maria G. Noval

Sophie N. Spector

Eric Bartnicki

Franco Izzo

9 more author(s)...
Description: This dataset includes microscopy images from paraffin embedding hematoxylin and eosin (H&E) as well as immunohistochemistry (IHC) staining’s for cleaved caspase-3, CD3 and CD11b. For these experiments, 6-8 week-old male and females mice from WT, Mavs+/- and Mavs-/- background were infected with 1E5 PFU of CHIKV, or mock-infected with (heat inactivated inoculum or PBS). Cardiac tissue was extracted...
Subject: Infectious Disease
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NYU Dataset

Alternate Title(s): MASALA
Authors: Alka Kanaya

Namratha Kandula

Nadia S. Islam
Description: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study examines risk factors for heart disease among South Asians of Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan descent in the United States to guide preventative measures and future treatments. Beginning in 2010, eligible South Asian participants between the ages of 40 and 80 were recruited from the San Francisco...
Subject: Chronic Disease

Genomics

Mental Health

Population Characteristics

Risk Factors
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NYU Dataset

Authors: Camila Delgado

Lei Bu

Jie Zhang

Fang-Yu Liu

4 more author(s)...
Description: The Purkinje cells (PCs) within the ventricular conduction system (VCS) has been widely investigated, because they are necessary for synchronous activation of the ventricular myocardium. This study identified genes that might influence PC development and VCS function. The differential transcriptional profiling revealed several highly enriched cell adhesion molecules in PCs. They uncovered two additional...
Subject: Genomics
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NYU Dataset

Authors: Natalia Eberhardt

Maria G. Noval

Ravneet Kaur

Letizia Amadori

19 more author(s)...
Description: This study combined multiple techniques (e.g., RNAscope in-situ hybridization, immunohistochemistry, immunofluorescence, single-cell RNA sequencing, bulk RNA sequencing, and functional assays) to investigate the inflammatory response associated with SARS-CoV-2 infection in human vascular tissues. Single cell RNA-sequencing data obtained from samples collected for this study is available via the Gene...
Subject: COVID-19

Infectious Disease

Risk Factors
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