NYU Dataset
GADD34 Promotes Fast Dephosphorylation of eIF2α and Elevation of Neuronal Protein Synthesis
Part of: Klann Lab |
UID: 10697
- Description
This study examined the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF). For the study, primary rodent neurons were exposed to BDNF and then examined for GADD34 protein levels. GADD34 is a protein phosphatase 1-targeting protein that directly binds to eukaryotic initiation factor 2α (eIF2α). This promotes eIF2α dephosphorylation and increases in de novo protein synthesis that supports memory consolidation. The dataset includes TRAP and RNA sequencing data. The results reveal that increases in protein synthesis resulting from neuronal activation require GADD34-induced eIF2α dephosphorylation.
C57BL/6J mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- Access to original TRAP-seq and RNA-seq data used in the paper are freely available on Gene Expression Omnibus (GEO).
- Grant Support
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