NYU Data Catalog

NYU Dataset

Authors: Erica M. Briggs

Wilson McKerrow

Paolo Mita

Jef D. Boeke

2 more author(s)...
Description: Long interspersed element-1 (LINE-1) is an autonomous retroelement that utilizes copy and paste mechanism to propagate themselves throughout the genome through a process called retrotransposition. The LINE-1 bicistronic mRNA codes for two proteins, ORF1p and ORF2. While LINE-1 transcription is usually repressed in most healthy somatic cells, ORF1p expression has been observed in tumors, including prostate...
Subject: Cancer

Genomics
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NYU Dataset

Authors: Mindong Ren

Yang Xu

Colin K. L. Phoon

Hediye Erdjument-Bromage

4 more author(s)...
Description: This study used proteomic analysis, respirometry, and electron microscopy to examine the development of condensed mitochondria. The dataset contains proteomic and imaging data. The data indicate that condensed mitochondria formed from orthodox mitochondria during meiosis in order to support the formation of the acrosomal matrix. Condensed mitochondria also respired more actively and contained more...
Subject: Proteomics
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NYU Dataset

Authors: Melissa J. Alldred

Sang Han Lee

Grace E. Stutzmann

Stephen D. Ginsberg
Description: Neurological dysfunction associated with Down syndrome (DS) is the concomitant basal forebrain cholinergic neuron (BFCN) degeneration and onset of Alzheimer’s disease (AD) pathology. Previously, single population RNA sequencing analysis in the Ts65Dn (Ts) mouse model of DS revealed that the mitochondrial oxidative phosphorylation pathway was significantly impacted, where a large subset of genes within...
Subject: Neuroscience
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NYU Dataset

Authors: Denise R. Minton

Minwoo Nam

Daniel J. McLaughlin

Jong Shin

7 more author(s)...
Description: Eukaryotic cells upregulate oxidative metabolism to maintain homeostasis upon glucose restriction. This study used CRISPR/Cas9-based screening to identify serine catabolic enzyme SHMT2. They found that the mitochondrial SHMT2 is required for robust mitochondrial oxygen consumption and low glucose proliferation. This dataset contains immunoblot images, as well as supplementary data tied to the publication....
Subject: Genomics
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NYU Dataset

Authors: Tessa J. Barrett

Emma M. Corr

Coen van Solingen

Florencia Schlamp

18 more author(s)...
Description: Psychological stress is linked with systemic inflammation. It accelerates inflammatory disease progression and monocytes are key in sustaining systemic inflammation. However, the mechanisms underlying stress-mediated inflammation and future health risk remains unknown. This study examined the impact of psychological stress on monocytes and showed that psychological stress induces remodeling of the...
Subject: Genomics
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NYU Dataset

Authors: Francisco J. Aulestia

Johnny Groeling

Guilherme H. Souza Bomfim

Veronica Costiniti

8 more author(s)...
Description: Fluoride is a naturally occurring mineral that helps build strong teeth and prevent cavities. However, excessive fluoride intake causes dental fluorosis, which are enamel defects that can increase the risk of tooth decay. This study examined the effects of fluoride exposure in enamel cells to assess its impact on calcium signaling. For their investigation, they isolated primary EO cells from Sprague...
Subject: Genomics
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NYU Dataset

Authors: Noelle V. Antao

Cherry Lam

Ari Davydov

Margot Riggi

6 more author(s)...
Description: Microsporidia are obligate intracellular pathogens that infect a wide range of invertebrate and vertebrate hosts, including humans. In humans, microsporidia most often infect the gastrointestinal tract and cause diarrheal diseases, but in immunocompromised patients, infections can be fatal. Previous knowledge of microsporidian intracellular development was based on 2D transmission electron microscopy...
Subject: Infectious Disease
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