NYU Data Catalog

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Results Found: 5
  • NYU Dataset

    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

    Authors
    Bryan Ngo
    Eugenie Kim
    Victoria Osorio-Vasquez
    Sophia Doll
    36 more author(s)...
    Description

    Brain metastasis is the most common intracranial malignancy in adults, which is often fatal. Studies have shown that brain metastases depend on cooperative cellular interactions between tumor cells and specialized cells within the central nervous system (CNS). Metabolic constraints imposed by the serine and glycine limited brain environment restrict metastatic tumor growth. This study showed that 3-phosphoglycerate...

    Subject
    Neuroscience
    Proteomics
    Access Rights
    Application Required
    Author Approval Required
  • NYU Dataset

    Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs Requires SHMT2

    Authors
    Denise R. Minton
    Minwoo Nam
    Daniel J. McLaughlin
    Jong Shin
    7 more author(s)...
    Description

    Eukaryotic cells upregulate oxidative metabolism to maintain homeostasis upon glucose restriction. This study used CRISPR/Cas9-based screening to identify serine catabolic enzyme SHMT2. They found that the mitochondrial SHMT2 is required for robust mitochondrial oxygen consumption and low glucose proliferation. This dataset contains immunoblot images, as well as supplementary data tied to the publication....

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis

    Authors
    Samantha W. Alvarez
    Vladislav O. Sviderskiy
    Erdem M. Terzi
    Thales Papagiannakopoulos
    5 more author(s)...
    Description

    This study performed loss-of-function screens in a transformed breast cell line using a metabolism-restricted short hairpin RNA (shRNA) library to understand differences in metabolic pathway requirements between in vitro model systems and in vivo tumors. They found that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. This dataset includes supplementary data tied...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    MicroRNA-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

    Authors
    Milessa Silva Afonso
    Monika Sharma
    Martin Schlegel
    Coen van Solingen
    11 more author(s)...
    Description

    MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Comprehensive Analysis of Regenerative and Transformed Liver

    Authors
    Daniel J. McLaughlin
    Hannan Mir
    Minwoo Nam
    Richard Possemato
    Description

    This study performed a differential transcriptomic and metabolomic analysis of benign proliferative and transformed liver. They used partial hepatectomy-induced liver regeneration and diethylnitrosamine (DEN) induced carcinogenesis to identify and analyze alterations specific to multiple regenerative and transformed tissue states. This dataset contains supplementary data tied to the publication. The...

    Subject
    Genomics
    Access Rights
    Free to All