This study performed a differential transcriptomic and metabolomic analysis of benign proliferative and transformed liver. They used partial hepatectomy-induced liver regeneration and diethylnitrosamine induced carcinogenesis to identify and analyze alterations specific to multiple regenerative and transformed tissue states. This dataset contains supplementary data tied to the publication. Supplementary data includes RNA sequencing data for quiescent and regeneration tumor samples, RNA sequencing data for quiescent and sham samples, relative abundance of metabolites from quiescent and regeneration tumor tissue samples, and relative abundance of metabolites from quiescent and regeneration plasma samples. In addition, there are data on concentration of lipid metabolites from quiescent and regeneration tissue samples, concentration of lipid metabolites from quiescent and regeneration plasma samples, order of metabolites and genes in heat maps, genotype of tumors analyzed for common oncogenes, and volcano plot.