Chemogenetic technology designer receptors exclusively activated by designer drugs (DREADD) is a widely used experimental method to control neuronal activity with an exogenous receptor. This study virally expressed an excitatory DREADD in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. For this study, Sprague Dawley rats were used for viral injection and intracranial...

Several spatial coding mechanisms are known to coexist in the hippocampus. However, how are they influenced by various environmental features is still unclear. This study investigated the spatial coding characteristics of hippocampal neurons in mice and rats navigating in different environments. C57BL/6 mice and Long-Evans rats were used in this study. For both mice and rats, most CA1 cells were recorded...

Place cells receive a disparate collection of excitatory and inhibitory currents that provide them with spatially selective discharges and rhythmic activity. This study combined intracellular and extracellular recordings with computational modeling and optogenetic or chemogenetic manipulations to examine the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. Homozygous CaMKIIa-Cre...

This study described a unique set of deep layer neurons in posterior parietal cortex (PPC) whose spiking activity is inversely correlated with all principal cells and interneurons in all brain states, but most commonly during the down state of non-REM (NREM) sleep. They identified down state-active (DSA) neurons as deep layer neocortical neurogliaform cells that express ID2 and Nkx2.1. For this study,...

Spike sequences are exemplified by memory replays in sharp-wave ripples (SWRs) and high-frequency oscillations resulting from pyramidal cell-interneuron interactions in the hippocampus. However, the microcircuitry mechanism that enables such flexible spike sequencing remains unknown. This study recorded the membrane potentials of multiple hippocampal CA1 pyramidal cells in mice. For this study, whole-cell...

This data was generated in a study to characterize brain bioenergetics in a cohort of clinically and cognitively normal women between the ages of 40 and 50 at different endocrine transition states including premenopause (n = 15), perimenopause (n = 14), and postmenopause (n = 14) in order to study the increased risk for Alzheimer’s disease in women. All subjects received clinical, laboratory, and neuropsychological...

This data contains information on patients with neurofibromatosis type 1 and neurofibromatosis type 2 and schwannomatosis. The neurofibromatoses (NF) are rare disorders with variation in clinical manifestations, and the NF Registry was created to assist researchers in studying the disease. Patients are included in the registry if they meet the diagnostic criteria for one of the three NF conditions....

This dataset was collected for a combined retrospective and prospective cross-sectional study to establish risk factors for infection after treatment for intracerebral hemorrhage and subarachnoid hemorrhage and to determine the impact of those infections on long-term outcomes. Data was harvested from Tisch Hospital records from January 2013 to December 2014 retrospectively and from January 2015 to...

This dataset was created as part of a prospective review of somatosensory evoked potential (SEP) recordings obtained during intraoperative monitoring (IOM) on instrumented spinal surgeries that were performed for chronic underlying neurologic and neuromuscular conditions, including scoliosis, myelopathy, and spinal stenosis, on patients who did not exhibit any postoperative neurologic deficits. For...

This dataset was compiled as part of a study to compare T1-T4 decrement between upper and lower extremity muscles as a way to investigate the difference between recovery time from a neuromuscular blocking agent (NMBA). The study analyzed the differences between recovery of the foot, abductor hallucis muscle, and hand, first dorsal interosseous muscle, by application of quantitative train-of-four (TOF)...