NYU Dataset

Model-Based Deep Brain Stimulation Programming for Parkinson’s Disease: The GUIDE Pilot Study

UID: 10335
* Corresponding Author
Description
This dataset was compiled as part of the Graphic User Interface for deep brain stimulation (DBS) Evaluation (GUIDE) study, a multicenter prospective pilot study designed to assess whether a computer-guided model could provide equally effective and more expeditious programming results when compared with the traditional, clinical deduced method of DBS programming of the subthalamic nucleus (STN). 26 subjects with Parkinson’s Disease (PD) were enrolled at two clinical sites: North Shore University Hospital and Evergreen Healthcare. 19 of the enrolled subjects were undergoing initial programming following DBS surgery, and 7 were undergoing reprogramming due to suboptimal results despite what was determined to be reasonable lead placement. Before each programming visit, a blinded rater performed the Unified Parkinson's Disease Rating Scale (UPDRS)-III examination of motor function. Subjects received both standard of care programming and programming based on a software program developed from the Cicerone Deep Brain Stimulation software v1.2. Optimal settings were determined iteratively throughout the study, after the comparison of the motor outcomes with these two interventions.
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Associated Publications
Study Type
Interventional
Data Collection Instruments
Unified Parkinson's Disease Rating Scale (UPDRS)-III Examination