Single-Cell Analysis of Localized Prostate Cancer
- Description
Prostate cancer (PCa) is the most common cancer diagnosis among men in the United States. This study characterized the tumor immune microenvironment of localized PCa, including high-grade prostate cancer (HGPCa) and low-grade prostate cancer (LGPCa) through single-cell RNA sequencing and multicolor flow cytometry of freshly isolated prostatectomy specimens. PCa tumor samples were collected from patients at the NYU Langone Health and the VA New York Harbor Healthcare System before undergoing radical prostatectomy. The proportion of tumor-infiltrating immune cells in freshly resected PCa tissue from a prospective cohort of 32 patients was examined by flow cytometry. To further explore the transcriptional profiles of these dominant immune cell subsets, single-cell RNA sequencing was used to analyze six fresh prostatectomy samples: three patient samples with HGPCa and three patient samples with LGPCa. This dataset includes single-cell RNA sequencing and flow cytometry data.
- Geographic Coverage
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New York (State) - New York City
Access
- Restrictions
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Application RequiredAuthor Approval Required
- Instructions
- Please complete the Data Request Form to request access to this dataset. The information included in the form will be sent to the Corresponding Author who will evaluate your request for their data. The Corresponding Author may ask you to provide additional information if necessary.