Transcription Factor RORα Enforces Stability of the Th17 Cell Effector Program
- Description
The transcription factor RORγt is important for T helper 17 (Th17) cell differentiation. This study examined the role of the closely-related RORα in regulating the Th17 effector program. For the study, mouse T cells were purified from lymph nodes and spleens of six to eight week old mice. The dataset includes RNA sequencing analysis of ex vivo Th17 cells from draining lymph nodes or spinal cords of the mixed bone marrow chimera mice. This study also contains ATAC sequencing analysis of in vitro or ex vivo Th17 cells, RORα ChIP sequencing analysis of in vitro Th17 cells, and RORγt ChIP sequencing analysis of in vitro Th17 cells. These data indicate that RORα functions as a key regulator for the Th17 effector program through direct regulation of sustained RORγt expression.
Access
- Restrictions
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Free to All
- Instructions
- RNA, ATAC, and ChIP sequencing raw and analyzed data generated during this study have been deposited at Gene Expression Omnibus (GEO).
- Grant Support
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Howard Hughes Medical Institute/Howard Hughes Medical InstituteHelen L. & Martin S. Kimmel Center for Stem Cell Biology/NYU Langone Health6-2021-0155/Yonsei University College of MedicineHV21C005001/Ministry of Health and Welfare, Republic of KoreaHV22C024901/Ministry of Health and Welfare, Republic of Korea2021R1C1C100691212/Ministry of Science and ICT, Republic of KoreaDale F. and Betty Ann Frey Fellowship/Damon Runyon Cancer Research FoundationHHMI Fellowship/Damon Runyon Cancer Research Foundation