NYU Data Catalog

NYU Dataset

Authors: Maria M. Steele

Ian D. Dryg

Dhaarini Murugan

Julia Femel

6 more author(s)...
Description: CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...
Subject: Cancer

Genomics
Access Rights: Application Required

Author Approval Required

NYU Dataset

Authors: Kwan Ho Tang

Shuai Li

Alireza Khodadadi-Jamayran

Jayu Jen

14 more author(s)...
Description: SHP2 plays critical roles in normal cell signaling and SHP2 inhibitors alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. This study showed that inhibiting the SHP2/RAS/ERK pathway triggers upregulation of CXCR2 ligands. In this study, C57BL/6J mice were used as the orthotopic allograft lung cancer model. They injected KP cells into the...
Subject: Cancer

Genomics
Access Rights: Free to All

NYU Dataset

Authors: Taylor A. Heim

Ziyan Lin

Maria M. Steele

Tenny Mudianto

1 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...
Subject: Genomics
Access Rights: Application Required

Author Approval Required

NYU Dataset

Authors: Ellie Ivanova

Jasmine Shwetar

Joseph C. Devlin

Terkild B. Buus

17 more author(s)...
Description: To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...
Subject: COVID-19

Genomics

Infectious Disease
Access Rights: Free to All

NYU Dataset

Authors: Taylor A. Heim

Austin C. Schultz

Ines Delclaux

Vanessa Cristaldi

2 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...
Subject: Genomics
Access Rights: Application Required

Author Approval Required

NYU Dataset

Authors: Mark Yarmarkovich

Quinlen F. Marshall

John M. Warrington

Rasika Premaratne

24 more author(s)...
Description: This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...
Subject: Cancer

Proteomics
Access Rights: Free to All

NYU Dataset

Alternate Title(s): Vaccine‐generated Immunity in Ocrelizumab‐treated Patients: Longitudinal Assessments (VIOLA)
Authors: Ilya Kister

Ryan Curtin

Amanda L. Piquet

Tyler Borko

16 more author(s)...
Description: This is a prospective, two-year study of immunity against SARS-CoV-2 in multiple sclerosis patients receiving ocrelizumab (OCR) at the time of COVID vaccination. Researchers recruited 60 patients (aged 18-65) from the NYU MS Comprehensive Care Center in New York City and the Rocky Mountain MS Center at the University of Colorado Anschutz Medical Center in Aurora, CO. Participants provided blood samples...
Subject: Chronic Disease

COVID-19
Access Rights: Free to All