NYU Data Catalog

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Results Found: 4
  • NYU Dataset

    ORF2p Eludes Detection in Mass Spectrometry-Based Tumor Proteome Profiling

    Authors
    Daniel Ardeljan
    Xuya Wang
    Mehrnoosh Oghbaie
    Martin S. Taylor
    15 more author(s)...
    Description

    This study showed that long interspersed element-1 (LINE-1) ORF2p expression is almost undetectable in human cancers. LINE-1 is the major driver of mobile DNA activity in humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. ORF2p expression is not well characterized in human tissues and cell lines. For the study,...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Protein Modifications Discovered Using Differential Tandem Mass Spectrometry Proteomics

    Authors
    Paolo Cifani
    Zhi Li
    Danmeng Luo
    Mark Grivainis
    3 more author(s)...
    Description

    This dataset was collected to present a spectral alignment method for the identification of protein modifications using high-resolution mass spectrometry proteomics. For this study, they used SAMPEI for spectral alignment-based modified peptide identification. SAMPEI is an open-source algorithm that is designed for the discovery of functional protein and peptide signaling modifications. Human OCI-AML2...

    Subject
    Genomics
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Hypothalamic Melanin-Concentrating Hormone Regulates Hippocampus-Dorsolateral Septum Activity

    Authors
    JingJing Liu
    Richard W. Tsien
    Zhiping P. Pang
    Description

    Hypothalamic melanin-concentrating hormone (MCH) polypeptide contributes to regulating energy homeostasis, sleep, and memory. However, the mechanistic bases of its effects are still unclear. This study found that the physiological mechanism underlying the functional role of MCH signaling in projections to the dorsolateral septum (dLS), which is a region involved in routing hippocampal firing rhythms...

    Subject
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors

    Authors
    Mark Yarmarkovich
    Quinlen F. Marshall
    John M. Warrington
    Rasika Premaratne
    24 more author(s)...
    Description

    This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All