NYU Data Catalog

NYU Dataset

Authors: Brandilyn A. Peters

Melissa Wilson

Una Moran

Anna Pavlick

5 more author(s)...
Description: This study characterized gut microbiome in pre-treatment stool using 16S rRNA gene and shotgun metagenome sequencing in melanoma patients undergoing immunotherapy. Transcriptional expression of metagenomic pathways was confirmed with metatranscriptome sequencing. Metatranscriptomics is important for determining expression of metagenomic functions in the microbial community. They also examined associations...
Subject: Genomics
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NYU Dataset

Authors: Maria M. Steele

Ian D. Dryg

Dhaarini Murugan

Julia Femel

6 more author(s)...
Description: CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...
Subject: Cancer

Genomics
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NYU Dataset

Authors: Ze-Yan Zhang

Yingwen Ding

Ravesanker Ezhilarasan

Tenzin Lhakhang

9 more author(s)...
Description: Although targeted cancer therapies have been successful, their efficacies are limited by the development of resistance driven by clonal evolution within tumors. This study developed a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. They showed that heterogeneous clones,...
Subject: Cancer

Genomics
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NYU Dataset

Authors: Iman Osman
Description: Since 2002, the Interdisciplinary Melanoma Cooperative Group (IMCG) at Perlmutter Cancer Center has maintained one of the largest clinicopathologic resources, the Melanoma Clinicopathological-Biospecimen Database and Repository, for research on patients 18 years old and over with melanoma or at high risk for melanoma. Clinical data is stored in a secure REDCap database which contains 653 fields to...
Subject: Cancer

Chronic Disease

Genomics

Risk Factors
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NYU Dataset

Authors: Veronica Davalos

Claudia D. Lovell

Richard Von Itter

Igor Dolgalev

17 more author(s)...
Description: This study described DNA methylation changes that accompany metastatic progression in melanoma patients and found localized methylation changes in the regulatory region of NR2F2. NR2F2 is an orphan-nuclear receptor that is essential for embryonic and neural crest cell (NCC) development. For this study, they examined DNA methylation profiles of NCCs and melanocytes as well as melanoma patient tissues...
Subject: Cancer

Genomics
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NYU Dataset

Authors: Taylor A. Heim

Ziyan Lin

Maria M. Steele

Tenny Mudianto

1 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...
Subject: Genomics
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NYU Dataset

Authors: Taylor A. Heim

Austin C. Schultz

Ines Delclaux

Vanessa Cristaldi

2 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...
Subject: Genomics
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