NYU Data Catalog

NYU Dataset

Authors: Sophie E. Ruff

Nikita Vasilyev

Evgeny Nudler

Susan K. Logan

1 more author(s)...
Description: Previous study showed that PIM1 phosphorylates the androgen receptor (AR), the primary therapeutic target in prostate cancer. This study examined the mechanism how PIM1 phosphorylation of AR alters its transcriptional activity. They identified the AR co-activator, 14-3-3 ζ, as an endogenous PIM1 substrate in LNCaP cells. Rapid immunoprecipitation and mass spectrometry of endogenous proteins on chromatin...
Subject: Cancer

Genomics

Proteomics
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NYU Dataset

Authors: Russell J. Ledet

Sophie E. Ruff

Yu Wang

Shruti Nayak

4 more author(s)...
Description: This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...
Subject: Cancer

Proteomics
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NYU Dataset

Authors: Ayana Sawai

Sarah Pfennig

Milica Bulajic

Alexander Miller

3 more author(s)...
Description: Polycomb repressive complexes (PRCs) are known for repressing transcription through histone modifications and chromatin compaction. The PRCs consist of two central protein complexes, PRC1 and PRC2, which are important for normal gene regulation and development. This study found that PRC1 is essential for the specification of segmentally restricted spinal motor neuron subtypes, while PRC2 activity is...
Subject: Genomics
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NYU Dataset

Authors: Yating Wang

Liming Hou

M. Behfar Ardehali

Robert E. Kingston

1 more author(s)...
Description: Elongin, an RNA polymerase II (RNAPII)-associated factor, has shown to stimulate transcriptional elongation in vitro. The Elongin complex is assumed to be required for transcriptional induction in response to cellular stimuli. However, the role of this complex during transcription has not been studied in vivo. This study performed comprehensive studies of the role of Elongin A, the largest subunit...
Subject: Genomics

Proteomics
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NYU Dataset

Authors: David Filipovic

Wenjie Qi

Omar Kana

Daniel Marri

4 more author(s)...
Description: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs). Most DREs in accessible chromatin are not bound by TCDD-activated AhR, and DREs accessible in multiple tissues can be bound in some and unbound in others. This...
Subject: Genomics
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NYU Dataset

Authors: Hui-Lan Hu

Kalanghad P. Srinivas

Shuoshuo Wang

Moses V. Chao

5 more author(s)...
Description: Single‐cell RNA sequencing (scRNA‐seq) has not been effectively used for exploring the interactions between the host cell and viral pathogens in latently infected cells. Therefore, this study used scRNA‐seq and single‐molecule sensitivity fluorescent in situ hybridization technologies to investigate host single‐cell transcriptome changes upon the reactivation of a human neurotropic virus, herpes simplex...
Subject: Genomics
Access Rights: Free to All