Chemogenetic technology designer receptors exclusively activated by designer drugs (DREADD) is a widely used experimental method to control neuronal activity with an exogenous receptor. This study virally expressed an excitatory DREADD in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. For this study, Sprague Dawley rats were used for viral injection and intracranial...

This study described a unique set of deep layer neurons in posterior parietal cortex (PPC) whose spiking activity is inversely correlated with all principal cells and interneurons in all brain states, but most commonly during the down state of non-REM (NREM) sleep. They identified down state-active (DSA) neurons as deep layer neocortical neurogliaform cells that express ID2 and Nkx2.1. For this study,...

This data was generated in a study to characterize brain bioenergetics in a cohort of clinically and cognitively normal women between the ages of 40 and 50 at different endocrine transition states including premenopause (n = 15), perimenopause (n = 14), and postmenopause (n = 14) in order to study the increased risk for Alzheimer’s disease in women. All subjects received clinical, laboratory, and neuropsychological...

This dataset was collected for a combined retrospective and prospective cross-sectional study to establish risk factors for infection after treatment for intracerebral hemorrhage and subarachnoid hemorrhage and to determine the impact of those infections on long-term outcomes. Data was harvested from Tisch Hospital records from January 2013 to December 2014 retrospectively and from January 2015 to...

Neuroanatomical Age Prediction Using R (NAPR) is a framework that provides network-based access to predictive modeling software running on a persistent Amazon Web Services (AWS) computing instance. External users may estimate the age of individual subjects using cortical thickness maps derived from their own locally processed T1-weighted whole brain MRI scans. The model was trained using healthy control...

This dataset was collected for a study to replicate previous work on hippocampal physiology predictive of successful encoding using an associative memory paradigm in a surgical intracranial electroencephalography (iEEG) group and extend those investigations to a chronic ambulatory iEEG population using RNS System devices (NeuroPace, Inc.). The primary objective was to compare the hippocampal gamma...

The NYU Alzheimer’s Disease Research Center (NYU ADRC) maintains a large database of standardized clinical and neuropathological research data collected at NYU Langone Health for local investigators, as well as those at affiliated or collaborating institutions. The NYU ADRC database includes a cumulative record of over 1,500 subjects enrolled since 1972. Data was collected every two years until 2005...

This dataset is composed of eight bilateral silicon-probe multi-cellular electrophysiological recordings performed on four male Long-Evans rats. These recordings were performed to assess the effect of novel spatial learning on hippocampal CA1 neural firing and LFP patterns in naïve animals. Each session consisted of a long (~4 hour) PRE rest/sleep epoch home-cage recordings performed in a familiar...

The data set contains recordings made from multiple anterior thalamic nuclei, mainly the antero-dorsal (AD) nucleus, and subicular areas, mainly the post-subiculum (PoS), in freely moving mice. Thalamic and subicular electrodes yielding high number of the so-called Head-Direction (HD) cells were likely to be located in the AD nucleus and the PoS, respectively. Electrode placement was confirmed by histology....

The data set contains multichannel simultaneous recordings made from layer CA1 of the right dorsal hippocampus of three Long-Evans rats during open field tasks in which the animals chased randomly placed drops of water or pieces of Froot Loops while on an elevated square platform. In order to examine the temporal relationships between theta oscillations and the coordination of neuronal firing in the...