NYU Dataset
RNA Sequencing Analysis of Caenorhabditis elegans DAF-18 During Primordial Germ Cell Quiescence
Part of: Jane Hubbard Lab |
UID: 10706
- Description
PTEN is one of the most frequently lost tumor suppressors in human cancers and regulates quiescence of stem cells and cancer cells. The Caenorhabditis elegans daf-18 gene encodes the worm version of PTEN. Previous studies showed that in worms that have lost daf-18 function, primordial germ cells (PGCs) inappropriately begin dividing in the L1 larvae hatched into starvation conditions. This study examined the role of daf-18 in maintaining PGC quiescence in L1 starvation. The dataset includes RNA sequencing and imaging data. The publication also includes supplementary data, which contains RNA sequencing results and analysis, and strains, plasmids and primers used in this study.
Access
- Restrictions
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Free to All
- Instructions
- Raw and processed RNA sequencing data are available on Gene Expression Omnibus (GEO). All other data are provided in the paper on PubMed Central (PMC) under Supplementary Materials.
- Grant Support
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132083-PF-18-029-01-DDC/American Cancer SocietyC029561/New York State Stem Cell Science
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