NYU Dataset
Forty-Hertz Light Stimulation Does Not Entrain Native Gamma Oscillations in Alzheimer’s Disease
Part of: Buzsaki Lab |
Part of: Oxytocin U19 BRAIN Initiative |
UID: 10678
- Description
Alzheimer’s disease (AD) is characterized by abnormal aggregation of the proteins amyloid-β (Aβ). Recent studies showed that 40-Hz sensory stimulation is a potential treatment in AD. This study examined whether 40-Hz flickering light entrains gamma oscillations and suppresses Aβ in the brains of APP/PS1 and 5xFAD mouse models. For the study, they investigated the effect of 40-Hz light stimulation on Aβ load at different stages of AD pathology in four cohorts of APP/PS1 and one cohort of 5xFAD mice. This dataset includes immunohistochemistry, electrophysiology, and behavioral data. These data indicate that 40-Hz flickering light does not reduce Aβ load in the neocortex or hippocampus.
5xFAD mice
C57BL/6J mice
APP/PS1 mice
Cx3cr1GFP/+:5xFAD+/− mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
-
Free to All
- Instructions
- The data that support the main findings of this study are publicly available on the Buzsaki Lab Webshare and supplementary data used in this study can be found at Allen Brain Atlas. The code used for this study are available on GitHub.
Leica Vibratome
Olympus BX61VS
- Grant Support
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Fisher Center for Alzheimer’s Research Foundation/Fisher Center for Alzheimer’s Research FoundationNI 2057/1–1/Deutsche Forschungsgemeinschaft Walter Benjamin FellowshipAARFD-17–533584/Alzheimer’s Association
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