Forty-Hertz Light Stimulation Does Not Entrain Native Gamma Oscillations in Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by abnormal aggregation of the proteins amyloid-β (Aβ). Recent studies showed that 40-Hz sensory stimulation is a potential treatment in AD. This study examined whether 40-Hz flickering light entrains gamma oscillations and suppresses Aβ in the brains of APP/PS1 and 5xFAD mouse models. For the study, they investigated the effect of 40-Hz light stimulation on Aβ load at different stages of AD pathology in four cohorts of APP/PS1 and one cohort of 5xFAD mice. This dataset includes electrophysiology, immunohistochemistry, and behavioral data. These data indicate that 40-Hz flickering light does not reduce Aβ load in the neocortex or hippocampus.