NYU Dataset
Ca2+ Channel ORAI1 Regulates Oral Cancer Growth and Nociceptive Pain
Part of: Lacruz Lab |
UID: 10664
- Description
This study described the function of the Ca2+ channel ORAI1 as an important regulator of oral cancer pain. Previous study showed that ORAI1 was highly expressed in tumor samples from patients with oral cancer. ORAI1 activation caused sustained Ca2+ influx in human oral cancer cells. To address the effects of ORAI1 in cell proliferation, HSC-3 cells were stimulated with 25 µM cyclopiazonic acid in the presence or absence of the ORAI inhibitor synta-66 for 3 hours before washing the cells and isolating the mRNA. The dataset includes RNA sequencing data, which indicates that ORAI1 regulated many genes encoding oral cancer markers such as metalloproteases and pain modulators.
Access
- Restrictions
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Free to All
- Instructions
- The RNA sequencing data have been deposited in Gene Expression Omnibus (GEO).
Thermo Scientific NanoDrop
- Grant Support
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AD105/NYU Abu Dhabi
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