NYU Dataset
Ca2+ Channel ORAI1 Regulates Oral Cancer Growth and Nociceptive Pain
Part of: Lacruz Lab |
UID: 10664
- Description
This study described the function of the Ca2+ channel ORAI1 as an important regulator of oral cancer pain. Previous study showed that ORAI1 was highly expressed in tumor samples from patients with oral cancer. ORAI1 activation caused sustained Ca2+ influx in human oral cancer cells. They analyzed the expression of ORAI1 in the human oral squamous cell carcinoma cell lines HSC-3 and SCC-9, in the dysplastic oral keratinocytes DOK cells, and in spontaneously transformed normal keratinocytes HaCaT cells. The dataset includes RNA sequencing data. RNA sequencing analysis indicate that ORAI1 regulated many genes encoding oral cancer markers such as metalloproteases and pain modulators.
HaCaT cells
HSC-3 cells
SCC-9 cells
DOK cells
TG neurons
C57BL/6J mice
NU/J Foxn1nu athymic mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
-
Free to All
- Instructions
- The RNA-seq data have been deposited in Gene Expression Omnibus (GEO). All other data needed to evaluate the conclusions in the paper are present on PubMed Central (PMC) under Supplementary Materials.
Thermo Scientific NanoDrop
- Grant Support
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AD105/NYU Abu Dhabi
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