Targeting Succinate Receptor Effectively Inhibits Periodontal Disease
- Description
Periodontal disease (PD) is induced by a bacterial dysbiosis in the oral cavity that stimulates inflammation and bone loss. This study showed elevation of succinate in PD, which aggravates the disease through the succinate receptor (SUCNR1). Targeted metabolomic analysis was performed to compare the succinate level in the subgingival plaque of patients with mild or severe periodontitis, where 28 gingival plaque samples collected from individuals (21 male and 7 female) without periodontitis (normal or mild gingivitis, N = 12) or severe periodontitis (N = 16). In addition, the association of systemic elevation of succinate with periodontitis was recapitulated in mice with induced experimental periodontitis. To induce periodontitis in SUCNR1 KO and WT mice, a ligature was placed around the second maxillary molar tooth for 5 days, followed by oral inoculation of Fusobacterium nucleatum to promote prolonged inflammation and dysbiosis. Then, loss and gain of function of SUCNR1 in periodontitis were compared between SUCNR1 KO and WT mice. This dataset contains 16S sequencing and microbiome data.
Access
- Restrictions
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Free to All
- Instructions
- Raw sequence reads are available on Sequence Read Archive (SRA) through BioProject and microbiome data and code used for downstream analysis are available on Zenodo.
- Grant Support