Targeting Succinate Receptor Effectively Inhibits Periodontal Disease
- Description
Periodontal disease (PD) is induced by a bacterial dysbiosis in the oral cavity that stimulates inflammation and bone loss. This study showed elevation of succinate in PD, which aggravates the disease through the succinate receptor (SUCNR1). Metabolomics assay compared the succinate level in the subgingival plaque of patients with PD. RNAscope and Immunofluorescence assays were conducted to validate the presence of SUCNR1 in both human and mouse gingival tissues. Loss and gain of function of SUCNR1 in PD were compared between SUCNR1 KO and WT mice. They developed a gel formulation of a small compound specifically blocking SUCNR1 to prevent and treat PD by inhibiting dysbiosis, inflammation, and bone loss. This dataset contains sequencing data. The data indicates succinate’s effect on PD pathogenesis and provides a topical treatment for this disease.
Access
- Restrictions
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Free to All
- Instructions
- Raw sequence reads are deposited at NCBI Sequence Read Archive (SRA) with BioProject and all original code has been deposited at Zenodo.
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