Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability
- Description
This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA) information, shRNA knockdown efficacy, and normalized population doublings upon shRNA expression relative to non-targeting shRNA, correlations between ISCU suppression sensitivity to suppression sensitivity of other genes across CCLE breast cancer cell lines, correlation of POLE sensitivity with gene expression in CCLE cell lines, RNA sequencing data for MDA-MB-231, CAMA-1, and MCF7 cells expressing shRNAs targeting POLE and either a vector control or cDNA POLE rescue, and primary phosphoproteomic data.
Access
- Restrictions
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Free to All
- Instructions
- RNA sequencing data are available at Gene Expression Omnibus (GEO) and data underlying figures can be accessed at Mendeley Data. All other data are available on PubMed Central (PMC) under Supplementary Material.
- Grant Support
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Pew Biomedical Scholars/Pew Charitable TrustsAlexander and Margaret Stewart Trust/Alexander and Margaret Stewart TrustACS Research Scholar Grant/American Cancer SocietySusan G. Komen for the Cure/Breast Cancer Foundation